par1 selective antagonist sch79797 Search Results


par1 antagonist vorapaxar  (Merck KGaA)
90
Merck KGaA par1 antagonist vorapaxar
Par1 Antagonist Vorapaxar, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/par1+selective+antagonist+sch79797/par1+antagonist+sch79797/pm31291665-40-11-16
Average 90 stars, based on 1 article reviews
par1 antagonist vorapaxar - by Bioz Stars, 2026-09
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par1 antagonist sch79797  (Biozol Diagnostica Vertrieb GmbH)
90
Biozol Diagnostica Vertrieb GmbH par1 antagonist sch79797
PAR-APs and thrombin activate cultured myenteric neurons . Representative traces of voltage sensitive dye recordings showing neuronal responses to a 2 s spritz application (indicated by the horizontal gray bar) of <t>PAR1-AP,</t> PAR2-AP, PAR4-AP, and thrombin. Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (A) Representative traces from cultured human myenteric neurons to human specific PAR-APs and thrombin show comparable responses to PAR1-AP and thrombin but no response to PAR2-AP and a minor response to PAR4-AP. (B) Guinea pig cultured myenteric neurons fire action potentials in response to PAR1-AP, PAR2-AP, PAR4-AP, and thrombin; the PAR4 response is rather moderate.
Par1 Antagonist Sch79797, supplied by Biozol Diagnostica Vertrieb GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/par1+selective+antagonist+sch79797/par1+antagonist+sch79797/pmc03439632-70-1-9
Average 90 stars, based on 1 article reviews
par1 antagonist sch79797 - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
par-1 receptor antagonist sch79797  (Schattauer GmbH)
90
Schattauer GmbH par-1 receptor antagonist sch79797
PAR-APs and thrombin activate cultured myenteric neurons . Representative traces of voltage sensitive dye recordings showing neuronal responses to a 2 s spritz application (indicated by the horizontal gray bar) of <t>PAR1-AP,</t> PAR2-AP, PAR4-AP, and thrombin. Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (A) Representative traces from cultured human myenteric neurons to human specific PAR-APs and thrombin show comparable responses to PAR1-AP and thrombin but no response to PAR2-AP and a minor response to PAR4-AP. (B) Guinea pig cultured myenteric neurons fire action potentials in response to PAR1-AP, PAR2-AP, PAR4-AP, and thrombin; the PAR4 response is rather moderate.
Par 1 Receptor Antagonist Sch79797, supplied by Schattauer GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/par1+selective+antagonist+sch79797/par1+antagonist+sch79797/pm22552808-112-20-16
Average 90 stars, based on 1 article reviews
par-1 receptor antagonist sch79797 - by Bioz Stars, 2026-09
90/100 stars
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Image Search Results


PAR-APs and thrombin activate cultured myenteric neurons . Representative traces of voltage sensitive dye recordings showing neuronal responses to a 2 s spritz application (indicated by the horizontal gray bar) of PAR1-AP, PAR2-AP, PAR4-AP, and thrombin. Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (A) Representative traces from cultured human myenteric neurons to human specific PAR-APs and thrombin show comparable responses to PAR1-AP and thrombin but no response to PAR2-AP and a minor response to PAR4-AP. (B) Guinea pig cultured myenteric neurons fire action potentials in response to PAR1-AP, PAR2-AP, PAR4-AP, and thrombin; the PAR4 response is rather moderate.

Journal: Frontiers in Neuroscience

Article Title: Activity of Protease-Activated Receptors in Primary Cultured Human Myenteric Neurons

doi: 10.3389/fnins.2012.00133

Figure Lengend Snippet: PAR-APs and thrombin activate cultured myenteric neurons . Representative traces of voltage sensitive dye recordings showing neuronal responses to a 2 s spritz application (indicated by the horizontal gray bar) of PAR1-AP, PAR2-AP, PAR4-AP, and thrombin. Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (A) Representative traces from cultured human myenteric neurons to human specific PAR-APs and thrombin show comparable responses to PAR1-AP and thrombin but no response to PAR2-AP and a minor response to PAR4-AP. (B) Guinea pig cultured myenteric neurons fire action potentials in response to PAR1-AP, PAR2-AP, PAR4-AP, and thrombin; the PAR4 response is rather moderate.

Article Snippet: The PAR1 antagonist SCH79797 (N 3 -cyclopropyl-7-[[4-(1-methylethyl)phenyl] methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride; Biozol Diagnostica, Eching, Germany) was dissolved in waterfree 100% dimethyl sulfoxide (Acros Organics, Geel, Belgium; Ahn et al., ).

Techniques: Cell Culture

Analysis of neural actions of PAR-APs and thrombin in cultured human and guinea pig myenteric neurons . The graphs represent (from top to bottom) the proportion of neurons per cluster responding to a specific PAR activator, the specific PAR activator evoked spike frequency and the neuroindex which is the product of spike frequency and proportion of responding neurons. Data are illustrated with scatter plots showing the 25%/75% and the bars indicating the 10%/90% percentiles. PAR1-AP induced the strongest effect in human myenteric neurons, whereas PAR4-AP evoked only weak responses and PAR2-AP no response. Thrombin also activated human myenteric neurons but to a lesser degree than PAR1-AP. The PAR1-AP effect in human neurons is blocked by the specific PAR1 antagonist SCH79797. In guinea pig myenteric neurons the responsiveness to PAR1-AP, PAR2-AP, and thrombin was similar, but PAR4-AP evoked a spike discharge in less neurons at a significantly lower frequency. *Indicates significant differences to PAR1-AP in human neurons; # indicates significant differences to PAR1-AP in guinea pig neurons. Numbers in parenthesis indicate numbers of tissue/clusters/neurons.

Journal: Frontiers in Neuroscience

Article Title: Activity of Protease-Activated Receptors in Primary Cultured Human Myenteric Neurons

doi: 10.3389/fnins.2012.00133

Figure Lengend Snippet: Analysis of neural actions of PAR-APs and thrombin in cultured human and guinea pig myenteric neurons . The graphs represent (from top to bottom) the proportion of neurons per cluster responding to a specific PAR activator, the specific PAR activator evoked spike frequency and the neuroindex which is the product of spike frequency and proportion of responding neurons. Data are illustrated with scatter plots showing the 25%/75% and the bars indicating the 10%/90% percentiles. PAR1-AP induced the strongest effect in human myenteric neurons, whereas PAR4-AP evoked only weak responses and PAR2-AP no response. Thrombin also activated human myenteric neurons but to a lesser degree than PAR1-AP. The PAR1-AP effect in human neurons is blocked by the specific PAR1 antagonist SCH79797. In guinea pig myenteric neurons the responsiveness to PAR1-AP, PAR2-AP, and thrombin was similar, but PAR4-AP evoked a spike discharge in less neurons at a significantly lower frequency. *Indicates significant differences to PAR1-AP in human neurons; # indicates significant differences to PAR1-AP in guinea pig neurons. Numbers in parenthesis indicate numbers of tissue/clusters/neurons.

Article Snippet: The PAR1 antagonist SCH79797 (N 3 -cyclopropyl-7-[[4-(1-methylethyl)phenyl] methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride; Biozol Diagnostica, Eching, Germany) was dissolved in waterfree 100% dimethyl sulfoxide (Acros Organics, Geel, Belgium; Ahn et al., ).

Techniques: Cell Culture

Response pattern to PAR-APs in guinea pig cultured myenteric neurons demonstrates receptor clustering . (A) Image shows outlines of a cluster of guinea pig cultured myenteric neurons stained with the voltage sensitive dye Di-8-ANEPPS. (B) Representative traces of a neuron [marked with a star in (A) ] that responded to PAR1-AP and PAR2-AP (2 s spritz application indicated by a gray horizontal bar). Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (C) Pairwise application of PAR-APs revealed functional coexpression patterns. Proportions of neurons responding to two PAR-APs are expressed relative to the proportion of neurons responding to any PAR-AP in that particular set of experiment (100%).

Journal: Frontiers in Neuroscience

Article Title: Activity of Protease-Activated Receptors in Primary Cultured Human Myenteric Neurons

doi: 10.3389/fnins.2012.00133

Figure Lengend Snippet: Response pattern to PAR-APs in guinea pig cultured myenteric neurons demonstrates receptor clustering . (A) Image shows outlines of a cluster of guinea pig cultured myenteric neurons stained with the voltage sensitive dye Di-8-ANEPPS. (B) Representative traces of a neuron [marked with a star in (A) ] that responded to PAR1-AP and PAR2-AP (2 s spritz application indicated by a gray horizontal bar). Recordings were made in four 2 s long recording periods with 5–6 s intervals in between (indicated by the symbol between the traces). Every peak represents an action potential. (C) Pairwise application of PAR-APs revealed functional coexpression patterns. Proportions of neurons responding to two PAR-APs are expressed relative to the proportion of neurons responding to any PAR-AP in that particular set of experiment (100%).

Article Snippet: The PAR1 antagonist SCH79797 (N 3 -cyclopropyl-7-[[4-(1-methylethyl)phenyl] methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride; Biozol Diagnostica, Eching, Germany) was dissolved in waterfree 100% dimethyl sulfoxide (Acros Organics, Geel, Belgium; Ahn et al., ).

Techniques: Cell Culture, Staining, Functional Assay